aplastic anemia evolving to myelodysplastic syndrome and later to a lymphoproliferative malignancy in a treated case of carcinoma breast: a case report emphasizing the importance of pet-ct in cutaneous t cell lymphoma

نویسندگان

subramanyam padma

department of nuclear medicine & pet/ct, amrita institute of medical sciences & research centre, cochin, kerala, india palaniswamy shanmuga sundaram

department of nuclear medicine & pet/ct, amrita institute of medical sciences & research centre, cochin, kerala, india

چکیده

although aplastic anemia (aa) and myelodysplastic syndrome (mds) are separate entities with different management, distinction between the two can be difficult on morphological basis due to hypocellularity of bone marrow. mds is one of the serious complications of aa. karyotyping is definitive in the diagnosis of mds. better and robust investigations like 18f-fluoro-deoxy-glucose positron emission tomography/computed tomography (18f-fdg pet-ct) are essential in high risk patients with haematological malignancies and in those relapsing within a short period of time after initiation of therapy or having refractory disease. it might be helpful in the development of individual treatment algorithms for these high-risk patients. there may be unique problems in hematological malignancies where the transformation of one pathology into another may be silent with no biomarkers that can predict this transformation e.g. transformation of mds from aa. studies have shown that immune suppression can lead to a variety of haematological and lymphoproliferative disorders which may co-exist. 18f-fdg pet-ct may be useful in identifying the primary or occult sites of malignancy and also can direct the site from which biopsy can be attempted. we present a patient with carcinoma right breast who developed hematological and lymphoproliferative disorders during the course of her treatment. in this case, aa transformed to mds with abnormal karyotype (chromosome 9 mutation) and then progressed further to manifest cutaneous t cell lymphoma before patient succumbed to her illness. immune mediated suppression of haemopoiesis has been considered the most important mechanism in this case.‎

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Aplastic anemia evolving to myelodysplastic syndrome and later to a lymphoproliferative malignancy in a treated case of carcinoma breast: A case report emphasizing the importance of PET-CT in cutaneous T cell lymphoma

Although aplastic anemia (AA) and myelodysplastic syndrome (MDS) are separate entities with different management, distinction between the two can be difficult on morphological basis due to hypocellularity of bone marrow. MDS is one of the serious complications of AA. Karyotyping is definitive in the diagnosis of MDS. Better and robust investigations like 18F-Fluoro-deoxy-Glucose Posi...

متن کامل

Aplastic anemia evolving to myelodysplastic syndrome and later to a lymphoproliferative malignancy in a treated case of carcinoma breast: A case report emphasizing the importance of PET-CT in cutaneous T cell lymphoma

Although aplastic anemia (AA) and myelodysplastic syndrome (MDS) are separate entities with different management, distinction between the two can be difficult on morphological basis due to hypocellularity of bone marrow. MDS is one of the serious complications of AA. Karyotyping is definitive in the diagnosis of MDS. Better and robust investigations like 18F-Fluoro-deoxyGlucose Positron Emissio...

متن کامل

a frame semantic approach to the study of translating cultural scripts in salingers franny and zooey

the frame semantic theory is a nascent approach in the area of translation studies which goes beyond the linguistic barriers and helps us to incorporate cognitive and cultural factors to the study of translation. based on rojos analytical model (2002b), which centered in the frames or knowledge structures activated in the text, the present research explores the various translation problems that...

15 صفحه اول

from linguistics to literature: a linguistic approach to the study of linguistic deviations in the turkish divan of shahriar

chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...

15 صفحه اول

a synchronic and diachronic approach to the change route of address terms in the two recent centuries of persian language

terms of address as an important linguistics items provide valuable information about the interlocutors, their relationship and their circumstances. this study was done to investigate the change route of persian address terms in the two recent centuries including three historical periods of qajar, pahlavi and after the islamic revolution. data were extracted from a corpus consisting 24 novels w...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of nuclear medicine

جلد ۲۵، شماره ۱، صفحات ۶۶-۶۹

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023